Rudd is currently starring in the first official run of Craig Wright's production alongside fellow cast members Michael Shannon and Ed Asner at the Cort Theater in New York, and fans flocked to see the show on Wednesday.
However, audience members in the orchestra section got a shock when they were showered in sick after a man fell ill in the mezzanine.
A source tells New York Magazine, ""The stench of the vomit was a little overwhelming, and many people were noticeably uncomfortable, and of course everyone who was vomited on left.""
The actors battled through the ruckus, but Rudd couldn't help but mention the incident during a speech he gave to boost donations for the Broadway Cares/Equity Fights Aids charity at the end of the performance.
The insider adds, ""At the end of the show, they all made jokes about it, Paul Rudd saying how as an actor, being able to move people to tears or to laughter is amazing - but moving them to puking is a whole different league.
""Then after the show, at the stage door, the actors said how they almost stopped the show because they didn't know the severity of the situation.""