Two Packers veterans, cornerback Al Harris and outside linebacker, Aaron Kampman, are both out for the season.
Packers head coach Mike McCarthy said both will have season-ending knee surgeries.
McCarthy went on to say coaches are still considering options for each of the positions as the team prepares to face the Detroit Lions in Detroit on Thanksgiving Day.
Harris and Kampman were hurt on separate plays in the second half and both were taken to the locker room during the game. McCarthy did not elaborate on their injures.